We used Trial Sequential Analysis to control risks of random errors (i.e. systematic errors leading to overestimation of benefits and underestimation of harms). We used the Cochrane 'Risk of bias' tool to assess the risks of bias (i.e. We used fixed-effect and random-effects Peto odds ratios (OR) with 95% confidence intervals (CI) for analysis of the review outcomes. Two review authors independently extracted data from the included trials. ![]() The interventions could have been compared with placebo, no intervention, or to each other in differing regimens. The interventions could have been gastric lavage, ipecacuanha, or activated charcoal, or various extracorporeal treatments, or antidotes. ![]() Randomised clinical trials assessing benefits and harms of interventions in people who have ingested a paracetamol overdose. We examined the reference lists of relevant papers identified by the search and other published reviews. We also searched the World Health Organization International Clinical Trials Registry Platform and database (US National Institute of Health) for any ongoing or completed trials (January 2017). We searched The Cochrane Hepato-Biliary Group Controlled Trials Register (January 2017), CENTRAL (2016, Issue 11), MEDLINE (1946 to January 2017), Embase (1974 to January 2017), and Science Citation Index Expanded (1900 to January 2017). To assess the benefits and harms of interventions for paracetamol overdosage irrespective of the cause of the overdose. These interventions include inhibiting the absorption of paracetamol from the gastrointestinal tract (decontamination), removal of paracetamol from the vascular system, and antidotes to prevent the formation of, or to detoxify, metabolites. There are various interventions to treat paracetamol poisoning, depending on the clinical status of the person. ![]() In high-income countries, paracetamol toxicity is a common cause of acute liver injury. Paracetamol is commonly taken in overdose either deliberately or unintentionally. Paracetamol (acetaminophen) is the most widely used non-prescription analgesic in the world.
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